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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PTPN22
All Species:
11.82
Human Site:
Y577
Identified Species:
26
UniProt:
Q9Y2R2
Number Species:
10
Phosphosite Substitution
Charge Score:
-0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9Y2R2
NP_057051.3
807
91705
Y577
S
S
T
S
L
F
S
Y
Y
N
S
H
D
S
L
Chimpanzee
Pan troglodytes
XP_513663
807
91678
Y577
S
S
T
S
L
F
S
Y
Y
N
S
N
D
S
L
Rhesus Macaque
Macaca mulatta
XP_001110241
807
91482
Y577
S
S
T
S
L
S
S
Y
Y
N
S
H
D
S
L
Dog
Lupus familis
XP_540240
893
101055
C662
S
S
T
T
L
F
S
C
Y
N
S
H
D
S
L
Cat
Felis silvestris
Mouse
Mus musculus
P29352
802
89696
S573
L
P
A
S
S
T
T
S
F
F
Y
S
N
P
H
Rat
Rattus norvegicus
NP_001099930
804
89584
A573
A
Q
L
P
A
S
S
A
A
S
S
S
Y
S
N
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506530
800
89754
Y567
S
S
S
V
E
L
N
Y
S
V
P
C
G
S
Q
Chicken
Gallus gallus
XP_001235234
775
85980
P547
G
Q
D
A
Q
G
P
P
C
T
V
P
T
S
P
Frog
Xenopus laevis
NP_001084841
660
74123
Q432
E
I
K
K
V
P
L
Q
E
S
P
K
S
F
E
Zebra Danio
Brachydanio rerio
NP_956963
570
64484
V342
K
P
P
R
L
R
S
V
Q
G
E
C
A
V
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_796904
967
106580
R596
N
K
G
I
S
K
D
R
P
S
Q
P
P
P
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
95.5
71.1
N.A.
71.1
69.2
N.A.
57.1
50.8
36.3
34.3
N.A.
N.A.
N.A.
N.A.
28.2
Protein Similarity:
100
99.8
97
77.9
N.A.
80.4
79.3
N.A.
68
64
50.9
49.9
N.A.
N.A.
N.A.
N.A.
44.7
P-Site Identity:
100
93.3
93.3
86.6
N.A.
6.6
20
N.A.
26.6
6.6
0
13.3
N.A.
N.A.
N.A.
N.A.
0
P-Site Similarity:
100
100
93.3
93.3
N.A.
26.6
33.3
N.A.
40
13.3
13.3
13.3
N.A.
N.A.
N.A.
N.A.
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
10
0
10
10
10
0
0
10
10
0
0
0
10
0
0
% A
% Cys:
0
0
0
0
0
0
0
10
10
0
0
19
0
0
0
% C
% Asp:
0
0
10
0
0
0
10
0
0
0
0
0
37
0
0
% D
% Glu:
10
0
0
0
10
0
0
0
10
0
10
0
0
0
10
% E
% Phe:
0
0
0
0
0
28
0
0
10
10
0
0
0
10
0
% F
% Gly:
10
0
10
0
0
10
0
0
0
10
0
0
10
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
28
0
0
10
% H
% Ile:
0
10
0
10
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
10
10
10
10
0
10
0
0
0
0
0
10
0
0
10
% K
% Leu:
10
0
10
0
46
10
10
0
0
0
0
0
0
0
37
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
10
0
0
0
0
0
10
0
0
37
0
10
10
0
10
% N
% Pro:
0
19
10
10
0
10
10
10
10
0
19
19
10
19
10
% P
% Gln:
0
19
0
0
10
0
0
10
10
0
10
0
0
0
19
% Q
% Arg:
0
0
0
10
0
10
0
10
0
0
0
0
0
0
0
% R
% Ser:
46
46
10
37
19
19
55
10
10
28
46
19
10
64
0
% S
% Thr:
0
0
37
10
0
10
10
0
0
10
0
0
10
0
0
% T
% Val:
0
0
0
10
10
0
0
10
0
10
10
0
0
10
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
37
37
0
10
0
10
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _